Focal cortical atrophy in multiple sclerosis: Relation to lesion load and disability

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Focal cortical atrophy in multiple sclerosis: relation to lesion load and disability.

Multiple sclerosis (MS) is thought to predominantly affect white matter (WM). Recently, however, loss of cortical gray matter has also been described. Little is known about the cause of cortical atrophy in MS, whether it occurs early in the disease course, and whether it affects all cortical regions equally or if there is a preferential pattern of focal cortical atrophy. An automated method was...

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Cortical lesion load associates with progression of disability in multiple sclerosis.

Cortical inflammatory lesions have been correlated with disability and cortical atrophy in multiple sclerosis. The extent to which cortical lesion load is associated with longer-term physical and cognitive disability in different multiple sclerosis phenotypes has not yet been investigated. Thus, a 5-year prospective longitudinal study was carried on in a large group of patients with multiple sc...

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Impairment, disability and fatigue in multiple sclerosis

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The longitudinal relation between brain lesion load and atrophy in multiple sclerosis: a 14 year follow up study.

BACKGROUND Studies have suggested that T2 lesion activity is prominent in early relapsing-remitting multiple sclerosis, whereas brain atrophy, while seen early, appears more evident in later progressive disease. The temporal relation between these processes remains unclear. OBJECTIVE To explore the association between changing brain lesion loads and subsequent tissue atrophy in multiple scler...

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[Sex-related differences in atrophy and lesion load in multiple sclerosis patients].

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ژورنال

عنوان ژورنال: NeuroImage

سال: 2007

ISSN: 1053-8119

DOI: 10.1016/j.neuroimage.2006.10.006